PU-48

Chemical Structure : PU-48

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货号: PC-26600Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PU-48 is a selective inhibitor of urea transporters UT-A and UT-B with IC50 of 0.32 uM (UT-A1), inhibits UT-B-facilitated urea transport with IC50 of 0.21 uM, 0.21 in human, 0.33 uM in rat, and 2.1 uM for human, rat, and mouse.
PU-48 does not affect non-UT-B-mediated transmembrane urea transport in erythrocytes.
PU-48 inhibits urea transport in rat terminal inner medullary collecting ducts (IMCDs).
PU-48 (100 mg/kg) significantly increased urea excretion in both wild-type mice and UT-B-null mice, did not change blood Na+, K+, or Cl− levels or nonurea solute excretion in rats and mice.

物理化学性质&存储条件

分子量	288.32
分子式	C14H12N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate

参考文献

1. Zhang ZY, et al. Pharmaceutics. 2018 Aug 8;10(3):124.

2. Ren H, et al. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72.

PU-48

生物&药学活性

物理化学性质&存储条件

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PU-48

生物&药学活性

物理化学性质&存储条件

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