PSSI-51 | SOCT inhibitor | Probechem Biochemicals

Chemical Structure : PSSI-51

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PSSI-51 (Peripheral selective SCOT inhibitor-51)

货号: PC-24691Not For Human Use, Lab Use Only.

PSSI-51 is a potent, peripheral selectice succinyl-CoA:3-ketoacid-CoA transferase (SCOT) inhibitor, inhibits peripheral tissue (i.e., muscle) SCOT activity and ketone oxidation.

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生物&药学活性

PSSI-51 is a potent, peripheral selectice succinyl-CoA:3-ketoacid-CoA transferase (SCOT) inhibitor, inhibits peripheral tissue (i.e., muscle) SCOT activity and ketone oxidation.
PSSI-51 binds within the oxyanion binding pocket of SCOT.
PSSI-51 selectively inhibits SCOT without interacting with canonical targets of diphenylbutylpiperidines (DPBPs).
PSSI-51 inhibits ketone oxidation and improves glycemia in obese mice.
PSSI-51 exhibits minimal brain penetration and lacks the adverse effects associated with DPBPs.

物理化学性质&存储条件

分子量	475.54
分子式	C28H27F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)isoindoline-1,3-dione

参考文献

1. Tabatabaei Dakhili SA, et al. iScience. 2025 Apr 3;28(5):112336.

PSSI-51 (Peripheral selective SCOT inhibitor-51)

生物&药学活性

物理化学性质&存储条件

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PSSI-51 (Peripheral selective SCOT inhibitor-51)

生物&药学活性

物理化学性质&存储条件

参考文献

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