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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-PSB-KK1415
PSB-KK1415

Chemical Structure : PSB-KK1415

CAS No.: 885896-26-4

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PSB-KK1415 (PSB-KK-1415)

货号: PC-21097Not For Human Use, Lab Use Only.

PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.
PSB-KK1415 displays >25-fold selectivity versus CB receptors, and shows minimal species differences.
PSB-KK1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.

物理化学性质&存储条件

分子量 462.94
分子式 C24H23ClN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-chlorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Fabisiak A, et al. Neurogastroenterol Motil. 2021 Mar;33(3):e14003.
2. Andhika B Mahardhika, et al. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. 

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