欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-PSB-24379
PSB-24379

Chemical Structure : PSB-24379

CAS No.:

加入收藏

PSB-24379 (PSB24379)

货号: PC-26703Not For Human Use, Lab Use Only.

PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM.
PSB-24379 reduced ATP hydrolysis in melanoma and breast cancer cell membranes and partially reverted ATP-mediated effects on T cell activation and proliferation in an ATP-rich environment.

物理化学性质&存储条件

分子量 637.65
分子式 C30H32N5O7PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((2R,3S,4R,5R)-3,4-Dihydroxy-5-(8-(naphthalen-1-ylthio)-6-((4-phenylbutyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen Phosphate

参考文献

1. Chunyang Bi, et al. J Med Chem. 2026 May 1. doi: 10.1021/acs.jmedchem.6c00054.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: