PRIMA-1 |CAS:5608-24-2 Probechem Biochemicals

Chemical Structure : PRIMA-1

CAS No.: 5608-24-2

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PRIMA-1 (PRIMA 1;PRIMA1)

货号: PC-45773Not For Human Use, Lab Use Only.

PRIMA-1 (PRIMA1) is a specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines.

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10 mg (Free Sample)	￥180	In stock
25 mg	￥880	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

PRIMA-1 (PRIMA1) is a specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines.
PRIMA-1 is efficacious against myeloma cells with differential p53 genotypes, causes the demethylation of TP73, through DNMT1 depletion, to subsequently enhance UPR.
PRIMA-1 selectively induces apoptosis and cell cycle arrest in p53 mutant cells compared to CAPAN-2 cells.

物理化学性质&存储条件

分子量	185.2203
分子式	C9H15NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)-

参考文献

1. Izetti P, et al. Invest New Drugs. 2014 Oct;32(5):783-94.

2. Bykov VJ, et al. Carcinogenesis. 2002 Dec;23(12):2011-8.

3. Teoh PJ, et al. Oncotarget. 2016 Sep 20;7(38):61806-61819.

PRIMA-1 (PRIMA 1;PRIMA1)

生物&药学活性

物理化学性质&存储条件

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PRIMA-1 (PRIMA 1;PRIMA1)

生物&药学活性

物理化学性质&存储条件

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