PQR514 | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : PQR514

CAS No.: 1927857-55-3

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PQR514 (PRQ-514)

货号: PC-73277Not For Human Use, Lab Use Only.

PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively.

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生物&药学活性

PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively.
PQR514 inhibits phosphorylated S6 ribosomal protein (pS6, Ser235/236) and phosphorylation PKB Ser473 in A2058 cells with IC50 of 17 and 68 nM, respectively.
PQR514 displays negligible interference with protein kinase activities at 10 uM in a KINOMEScan panel.
PQR514 exhibits growth inhibition in vitro across a panel of 66 tumor cells with GI50 of 0.25 uM.
PQR514 demonstrates significant antitumor activity aginst OVCAR-3 human ovarian cancer xenograft model in BALB/c nude mice.

物理化学性质&存储条件

分子量	394.387
分子式	C16H20F2N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(Difluoromethyl)-5-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-2-pyrimidinamine

参考文献

1. Chiara Borsari, et al. ACS Med Chem Lett. 2019 Sep 3;10(10):1473-1479.

PQR514 (PRQ-514)

生物&药学活性

物理化学性质&存储条件

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PQR514 (PRQ-514)

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物理化学性质&存储条件

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