Torkinib (PP-242) | mTOR inhibitor | Probechem Biochemicals

Chemical Structure : PP242

CAS No.: 1092351-67-1

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PP242 (Torkinib, PP-242)

货号: PC-42608Not For Human Use, Lab Use Only.

Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.

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生物&药学活性

Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
Torkinib (PP242) shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM).
Torkinib (PP242) blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.

物理化学性质&存储条件

分子量	308.3378
分子式	C16H16N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-

参考文献

1. Janes MR, et al. Nat Med. 2010 Feb;16(2):205-13.

2. Feldman ME, et al. PLoS Biol. 2009 Feb 10;7(2):e38.

3. Hoang B, et al. J Biol Chem. 2012 Jun 22;287(26):21796-805.

4. Hsieh AC, et al. Cancer Cell. 2010 Mar 16;17(3):249-61.

PP242 (Torkinib, PP-242)

生物&药学活性

物理化学性质&存储条件

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PP242 (Torkinib, PP-242)

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物理化学性质&存储条件

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