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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Elastase-POL6014
POL6014

Chemical Structure : POL6014

CAS No.: 906547-89-5

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POL6014 (Lonodelestat, POL-6014)

货号: PC-25806Not For Human Use, Lab Use Only.

POL6014 (Lonodelestat, POL-6014) is a potent, selective, reversible and orally inhaled neutrophil elastase (NE) inhibitor, shows potential for cystic fibrosis (CF).

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

POL6014 (Lonodelestat, POL-6014) is a potent, selective, reversible and orally inhaled neutrophil elastase (NE) inhibitor, shows potential for cystic fibrosis (CF).

物理化学性质&存储条件

分子量 1478.76
分子式 C71H111N15O19
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclo[L-alanyl-L-seryl-L-isoleucyl-L-prolyl-L-prolyl-L-glutaminyl-L-lysyl-L-tyrosyl-D-prolyl-L-prolyl-(2S)-2-aminodecanoyl-L-α-glutamyl-L-threonyl]

参考文献

1. Barth P, et al. J Cyst Fibros. 2020 Mar;19(2):299-304.

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