PNU-282987 | α7 nAChR agonist | Probechem Biochemicals

Chemical Structure : PNU-282987

CAS No.: 123464-89-1

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PNU-282987 (PNU282987)

货号: PC-43108Not For Human Use, Lab Use Only.

PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM).

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10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM).
PNU-282987 is inactive at all tested monoamine, muscarine, glutamate, and GABA receptors.
PNU-282987 evokes whole-cell currents from cultured rat hippocampal neurons, improves the inherent hippocampal gating deficit occurring in a subpopulation of anesthetized rats, and enhances amphetamine-induced hippocampal oscillation; enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats.

物理化学性质&存储条件

分子量	301.2115
分子式	C14H18Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 61 mg/mL
Chemical Name/SMILES	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-, hydrochloride (1:1)

参考文献

1. Hajós M, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):1213-22.

2. Bodnar AL, et al. J Med Chem. 2005 Feb 24;48(4):905-8.

3. Su X, et al. Am J Respir Cell Mol Biol. 2007 Aug;37(2):186-92.

4. Hu M, et al. Brain Res. 2007 Jun 2;1151:227-35.

PNU-282987 (PNU282987)

生物&药学活性

物理化学性质&存储条件

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PNU-282987 (PNU282987)

生物&药学活性

物理化学性质&存储条件

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