PMM-172 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : PMM-172

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PMM-172 (PMM172)

货号: PC-24629Not For Human Use, Lab Use Only.

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生物&药学活性

PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM.
PMM-172 induced apoptosis in MDA-MB-231 cells in dose- and time- dependent manners.
PMM-172 reduced mitochondrial transmembrane potential in MDA-MB-231 cells.
PMM-172 reduced constitutive pSTAT3 (Tyr705) and inducible STAT3 activation in MDA-MB-231 cells.
PMM-172 does not inhibits phosphorylation or expression of STAT1 and STAT5.
PMM-172 suppressed STAT3 nuclear localization, and inhibited STAT3 downstream target genes expression.

物理化学性质&存储条件

分子量	566.58
分子式	C28H26N2O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 2-((5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetate

参考文献

1. Han-Yue Qiu, et al. Sci Rep. 2017 Jun 6;7(1):2863.

PMM-172 (PMM172)

生物&药学活性

物理化学性质&存储条件

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PMM-172 (PMM172)

生物&药学活性

物理化学性质&存储条件

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