PM289 | CB2R agonist | Probechem Biochemicals

Chemical Structure : PM289

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PM289 (PM-289)

货号: PC-27323Not For Human Use, Lab Use Only.

PM289 is a high affinity, selective Cannabinoid 2 Receptor (CB2R) agonist with Ki of 92.6 nM (hCB2), >300-fold selectivity over hCB1 receptors.

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生物&药学活性

PM289 is a high affinity, selective Cannabinoid 2 Receptor (CB2R) agonist with Ki of 92.6 nM (hCB2), >300-fold selectivity over hCB1 receptors.
PM289 attenuates NFκB activation in response to TNFα.
PM289 reduces forskolin-stimulated cAMP accumulation in HEK293-CB2R cells in a CB2-dependent manner.
PM289 attenuates TNFα-induced upregulation of ICAM-1.
PM289 reduces barrier disruption in brain microvascular endothelial cells.
PM289 increases wound repair in brain endothelial cells.
PM289 attenuates NFκB activation in response to TNFα.
PM289 modulates morphine-induced antinociceptive effect and withdrawal syndrome in rat model of knee osteoarthritis-associated pain, including both sexes.

物理化学性质&存储条件

分子量	384.56
分子式	C24H36N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1,1-Dimethylheptyl)-2-ethyl-2,4-dihydro-9-methoxy-4,4-dimethylchromeno[4,3-c]pyrazole

参考文献

1. Bullock TA, et al. NeuroImmune Pharm Ther. 2023 Oct 16;2(4):387-400.

2. Garcia MM, et al. Neuropharmacology. 2026 Jul 1;299:111090.

PM289 (PM-289)

生物&药学活性

物理化学性质&存储条件

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PM289 (PM-289)

生物&药学活性

物理化学性质&存储条件

参考文献

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