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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)-PM-4321
PM-4321

Chemical Structure : PM-4321

CAS No.: 2648155-86-4

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PM-4321 (PM4321)

货号: PC-26733Not For Human Use, Lab Use Only.

PM-4321 is a potent, selective aryl hydrocarbon receptor (AhR) modulator profiled as part of an AhR antagonist, inhibits TCDD-induced AhR activation with IC50 of 2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PM-4321 is a potent, selective aryl hydrocarbon receptor (AhR) modulator profiled as part of an AhR antagonist, inhibits TCDD-induced AhR activation with IC50 of 2 nM.
PM-4321 demonstrates potent antagonism toward endogenous AhR agonists 6-formylindolo[3,2-b]carbazole and kynurenine at concentrations of 2 and 20 nM, respectively.
PM-4321 exhibits potent AhR antagonistic properties in development for cancer immunotherapy.

物理化学性质&存储条件

分子量 441.41
分子式 C22H18F3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-hydroxy-2-methylpropyl)-5-(pyridin-3-yl)-7-(6-(trifluoromethyl)pyridin-3-yl)pyrido[3,4-d]pyridazin-1(2H)-one

参考文献

1. Kumar S, et al. Drug Metab Dispos. 2026 Mar 28;54(5):100285.

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