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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-PLX7922
PLX7922

Chemical Structure : PLX7922

CAS No.: 1638772-61-8

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PLX7922 (PLX-7922)

货号: PC-28186Not For Human Use, Lab Use Only.

PLX7922 is a potent, selective RAF inhibitor, binds with BRAFV600E, inhibits pERK in BRAFV600E cell lines and activates pERK in mutant NRAS cell lines.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PLX7922 is a potent, selective RAF inhibitor, binds with BRAFV600E, inhibits pERK in BRAFV600E cell lines and activates pERK in mutant NRAS cell lines.

物理化学性质&存储条件

分子量 464.58
分子式 C20H25FN6O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-N-ethyl-N-methylsulfamide

参考文献

1. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.

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