PINAD-1 | MALAT1 degrader | Probechem Biochemicals

Chemical Structure : PINAD-1

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PINAD-1 (PINAD 1, PINAD1)

货号: PC-28723Not For Human Use, Lab Use Only.

PINAD-1 is a first-in-class small molecule that selectively induces the degradation of MALAT1 with Kd of 2.5 uM, achieving an 85% reduction in MALAT1 transcript levels at 5 uM on MCF-7 cells, induces specific cleavage of the MALAT1 transcript in vitro and in cellulo.

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生物&药学活性

PINAD-1 is a first-in-class small molecule that selectively induces the degradation of MALAT1 with Kd of 2.5 uM, achieving an 85% reduction in MALAT1 transcript levels at 5 uM on MCF-7 cells, induces specific cleavage of the MALAT1 transcript in vitro and in cellulo.

物理化学性质&存储条件

分子量	832.02
分子式	C43H61N9O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(17-(2-((dimethylamino)methyl)-1H-imidazol-1-yl)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)-N-(3-methoxybenzyl)-N-(5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)butanamide

参考文献

1. Brega CAT, et al. Chemistry. 2026 Apr 22;32(15):e00025.

PINAD-1 (PINAD 1, PINAD1)

生物&药学活性

物理化学性质&存储条件

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PINAD-1 (PINAD 1, PINAD1)

生物&药学活性

物理化学性质&存储条件

参考文献

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