PIK001 (PIK-001)

Chemical Structure : PIK001

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货号: PC-25657Not For Human Use, Lab Use Only.

PIK001 (PIK-001) is a potent, specific small molecule PIKfyve inhibitor with IC50 of 10 nM.

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生物&药学活性

PIK001 (PIK-001) is a potent, specific small molecule PIKfyve inhibitor with IC50 of 10 nM.
PIK001 demonstrates potent and specific anti MM activity, with IC50s of 40, 20, and 40 nM in KMS26, JJN3, and KMS11, respectively.
PIK001 shows <10% inhibition in 89% of kinases included in a broad 377 kinase panel, with only four kinases (CK1G2, RIPK2, VRK1, BMPR1B) being inhibited >20%, at 1 uM.
PIK001 disrupts lysosomal function and autophagy, promoting cellular vacuolation.
PIK001 (50 nM, 72 h) increased cell surface expression of MHC class I in the parental sensitive KMS26 and KMS11 HMCLs.
PIK001 showed anti-MM activity in the nanomolar range with minimal cytotoxic activity on normal human PBMCs.

物理化学性质&存储条件

分子量	414.47
分子式	C22H22N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(5-(2-(3-methylbenzylidene)hydrazineyl)-2-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)morpholine

参考文献

1. Bonolo De Campos C, et al. Blood. 2025 Nov 5:blood.2025030061.

PIK001 (PIK-001)

生物&药学活性

物理化学性质&存储条件

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PIK001 (PIK-001)

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物理化学性质&存储条件

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