PFE-360 (PF-06685360, PF360)

Chemical Structure : PFE-360

CAS No.: 1527475-61-1

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货号: PC-62508Not For Human Use, Lab Use Only.

PFE-360 (PF-06685360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PFE-360 (PF-06685360, PF360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.
PFE-360 induces a morphological kidney phenotype resembling that of the LRRK2 ko rats, whereas no effects in the lung.
PFE-360 treatment induces morphological changes characterised by darkened kidneys and progressive accumulation of hyaline droplets in the renal proximal tubular epithelium, the estimated PFE-360 unbound plasma concentration off 10-fold the IC50 (30 nM) to achieve full peripheral LRRK2 inhibition.

物理化学性质&存储条件

分子量	308.345
分子式	C16H16N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrrole-2-carbonitrile

参考文献

1. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.

2. Andersen MA, et al. Toxicology. 2018 Feb 15;395:15-22.