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首页-小分子抑制剂&激动剂-Others-Other Targets-PF-6808472
PF-6808472

Chemical Structure : PF-6808472

CAS No.: 2088112-70-1

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PF-6808472 (XO44)

货号: PC-62860Not For Human Use, Lab Use Only.

PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency, could bind in CDK2 and CDK1, labels CDK4 proteins in cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency, could bind in CDK2 and CDK1, labels CDK4 proteins in cells.
PF-6808472 (XO44) covalently modifies up to 133 endogenous kinases, efficiently competes with high intracellular concentrations of ATP.
PF-6808472 (XO44) an useful tool in demanding chemoproteomic applications.

物理化学性质&存储条件

分子量 538.602
分子式 C25H27FN8O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-{4-[4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-prop-2-ynylcarbamoyl-pyrimidin-2-yl]-piperazin-1-ylmethyl}-benzenesulfonyl fluoride

参考文献

1. Zhao Q, et al. J Am Chem Soc. 2017 Jan 18;139(2):680-685.

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