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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Breast Tumor Kinase (BRK;PTK6)-PF-6683324
PF-6683324

Chemical Structure : PF-6683324

CAS No.: 1799788-94-5

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PF-6683324 (PF6683324)

货号: PC-35187Not For Human Use, Lab Use Only.

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays, also is a potent pan-TRK inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays, also is a potent pan-TRK inhibitor.
PF-6683324 inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.7 uM.
PF-6683324 demonstrates superior kinase selectivity compared to the Type I inhibitors.

物理化学性质&存储条件

分子量 521.473
分子式 C24H23F4N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((3S,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide

参考文献

1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.

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