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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-PF-46396
PF-46396

Chemical Structure : PF-46396

CAS No.: 1207481-21-7

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PF-46396 (PF 46396;PF46396)

货号: PC-60408Not For Human Use, Lab Use Only.

PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
    PF-46396 exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.

    物理化学性质&存储条件

    分子量 454.537
    分子式 C27H29F3N2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one

    参考文献

    1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7.

    2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97.

    3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.

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