PF-4618433 (PF4618433)

Chemical Structure : PF-4618433

CAS No.: 1166393-85-6

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货号: PC-62799Not For Human Use, Lab Use Only.

PF-4618433 (PF4618433) is a highly potent, selective PYK2 inhibitor with IC50 of 637 nM, promotes osteogenesis of hMSC cultures.

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生物&药学活性

PF-4618433 (PF4618433) is a highly potent, selective PYK2 inhibitor with IC50 of 637 nM, promotes osteogenesis of hMSC cultures.

PF-4618433 showed improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.

分子量	445.527
分子式	C24H27N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[3-[(3-pyridinyloxy)methyl]-1H-pyrazol-5-yl]urea

1. Han S, et al. J Biol Chem. 2009 May 8;284(19):13193-201.