PF-07853578 | PNPLA3 I148M degrader | Probechem Biochemicals

Chemical Structure : PF-07853578

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PF-07853578 (PF 07853578)

货号: PC-24670Not For Human Use, Lab Use Only.

PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM.

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生物&药学活性

PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM.

物理化学性质&存储条件

分子量	408.84
分子式	C16H19ClF2N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidinecarboxylic acid, 3,3-difluoro-5-[(5R)-5-methyl-1,1-dioxido-2-isothiazolidinyl]-, 4-chlorophenyl ester, (5R)-

参考文献

1. Patent WO2024084363 A1.

PF-07853578 (PF 07853578)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-07853578 (PF 07853578)

生物&药学活性

物理化学性质&存储条件

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