PF-07293623 | eIF4E inhibitor | Probechem Biochemicals

Chemical Structure : PF-07293623

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PF-07293623 (PF07293623)

货号: PC-26557Not For Human Use, Lab Use Only.

PF-07293623 is a first-in-class, specific eukaryotic initiation factor 4E (eIF4E) cap-binding domain inhibitor, inhibits protein synthesis and disrupts eIF4E binding to the m7G cap.

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生物&药学活性

PF-07293623 is a first-in-class, specific eukaryotic initiation factor 4E (eIF4E) cap-binding domain inhibitor, inhibits protein synthesis and disrupts eIF4E binding to the m7G cap.
PF-07293623 does not affect total levels of eIF4E or co-associated proteins such as eIF4G, eIF4A, and 4EBP1.
PF-07293623 treatment (100 nM) strikingly blocked binding of eIF4E to the m7G cap analog and increased the levels of unbound eIF4E in the flow through fraction in LuCaP 176 cells.
PF-07293623 treatment led to a decrease in eIF4E phosphorylation at serine 209.
PF-07293623 induces lineage plasticity through BAP1 and OTUD3 in LuCaP 176 cells, drives lineage plasticity and sensitization to enzalutamide in vivo.

物理化学性质&存储条件

分子量	702.18
分子式	C35H30ClF2N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(5-chloro-2-(3-(5-cyano-6-((1-(2,2-difluoropropyl)piperidin-4-yl)(methyl)amino)-2-methyl-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl)prop-1-yn-1-yl)phenyl)thieno[3,2-b]pyridine-3-carboxylic acid

参考文献

1. Rashmi Mishra, et al. J Clin Invest. 2026 Apr 14:e199838.

PF-07293623 (PF07293623)

生物&药学活性

物理化学性质&存储条件

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PF-07293623 (PF07293623)

生物&药学活性

物理化学性质&存储条件

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