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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-PF-06952229
PF-06952229

Chemical Structure : PF-06952229

CAS No.: 1801333-55-0

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PF-06952229 (MDV6058, PF 06952229)

货号: PC-72619Not For Human Use, Lab Use Only.

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM, specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction (94% inhibition of pSMAD at 0.5 uM), shows with potential antineoplastic activity.

物理化学性质&存储条件

分子量 458.918
分子式 C23H24ClFN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)amino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide

参考文献

1. Brahmam Pujala, et al. Bioorg Med Chem Lett. 2022 Sep 8;128979.

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