PF-06862309 | PI3Kα inhibitor | Probechem Biochemicals

Chemical Structure : PF-06862309

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PF-06862309 (PF-06843195 phosphate ester prodrug)

货号: PC-49022Not For Human Use, Lab Use Only.

PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM.

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生物&药学活性

PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM.
PF-06862309 demonstrated robust PK/PD correlation and tumor growth inhibition (TGI) in mouse xenograft models with MDAMB361 and MCF7 cell lines.
PF-06862309 is a clinical candidate for treating breast cancer patients characterized with ER+ , HER2-, and harboring PIK3CA mutations.

物理化学性质&存储条件

分子量	578.446
分子式	C20H26F3N8O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2-difluoroethyl (S)-3-((2'-amino-5-fluoro-2-morpholino-[4,5'-bipyrimidin]-6-yl)amino)-3-((phosphonooxy)methyl)pyrrolidine-1-carboxylate

参考文献

1. Cheng H, et al. J Med Chem. 2021 Jan 14;64(1):644-661.

PF-06862309 (PF-06843195 phosphate ester prodrug)

生物&药学活性

物理化学性质&存储条件

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PF-06862309 (PF-06843195 phosphate ester prodrug)

生物&药学活性

物理化学性质&存储条件

参考文献

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