PF-06843195 | PI3Kα inhibitor | Probechem Biochemicals

Chemical Structure : PF-06843195

CAS No.: 2067281-51-8

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PF-06843195 (PF06843195)

货号: PC-49021Not For Human Use, Lab Use Only.

PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ.

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5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ.
PF-06843195 also demonstrated high selectivity over mTOR.
PF-06843195 is a potent inhibitor of both PI3Kα (Ki< 0.018 nM) and PI3Kδ (Ki< 0.28 nM), but found to be 9-fold selective for PI3Kα over PI3Kδ in cell assays.
PF-06843195 is selective over two other members of the class I catalytic PI3K kinase group, PI3Kβ and PI3Kγ, >100- and >10 000-fold, respectively, in biochemical assays and 20-fold selective over PI3Kβ in cell assays.

物理化学性质&存储条件

分子量	498.467
分子式	C20H25F3N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)-4,5'-bipyrimidin-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate

参考文献

1. Cheng H, et al. J Med Chem. 2021 Jan 14;64(1):644-661.

PF-06843195 (PF06843195)

生物&药学活性

物理化学性质&存储条件

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PF-06843195 (PF06843195)

生物&药学活性

物理化学性质&存储条件

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