Zimlovisertib (PF-06650833) | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : PF-06650833

CAS No.: 1817626-54-2

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PF-06650833 (PF06650833, Zimlovisertib)

货号: PC-45740Not For Human Use, Lab Use Only.

Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM.
Zimlovisertib (PF-06650833) has IC50 of 2 nM in the PBMC assay as well as in a human whole blood assay.
Zimlovisertib (PF-06650833) shows excellent kinase selectivity in a panel of 278 kinases.
Zimlovisertib (PF-06650833) significantly inhibits LPS-induced TNFα in a dose dependent manner in rats model (0.3-30 mg/kg).
Zimlovisertib (PF-06650833) has favorable in vitro and in vivo ADME profiles and orally active.

物理化学性质&存储条件

分子量	361.3675
分子式	C18H20FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-

参考文献

1. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.

2. Seganish WM. Expert Opin Ther Pat. 2016 Aug;26(8):917-32.

PF-06650833 (PF06650833, Zimlovisertib)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-06650833 (PF06650833, Zimlovisertib)

生物&药学活性

物理化学性质&存储条件

参考文献

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