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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-PF-06305591
PF-06305591

Chemical Structure : PF-06305591

CAS No.: 1449473-97-5

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PF-06305591 (PF06305591;PF 06305591)

货号: PC-35885Not For Human Use, Lab Use Only.

PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
PF-06305591 displays excellent preclinical in vitro ADME and safety profile.

物理化学性质&存储条件

分子量 274.368
分子式 C15H22N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide

参考文献

1. Brown AD, et al. Bioorg Med Chem. 2019 Jan 1;27(1):230-239.

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