PF-04957325 | PDE8 inhibitor | Probechem Biochemicals

Chemical Structure : PF-04957325

CAS No.: 1305115-80-3

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PF-04957325 (PF 04957325)

货号: PC-38701Not For Human Use, Lab Use Only.

PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
PF-04957325 potentiates adrenocorticotropin stimulation of steroidogenesis by increasing cAMP-dependent protein kinase activity in both primary isolated adrenocortical cells and Y-1 cells.
PF-04957325 inhibits breast cancer cell migration by activation of cAMP signaling.

物理化学性质&存储条件

分子量	400.38
分子式	C14H15F3N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine

参考文献

1. Tsai LC, et al. Mol Pharmacol. 2011 Apr;79(4):639-48.

2. Shimizu-Albergine M, et al. Mol Pharmacol. 2012 Apr;81(4):556-66.

3. Dong H, et al. Breast Cancer Res Treat. 2015 Jul;152(1):17-28.

PF-04957325 (PF 04957325)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-04957325 (PF 04957325)

生物&药学活性

物理化学性质&存储条件

参考文献

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