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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-PF-00610355
PF-00610355

Chemical Structure : PF-00610355

CAS No.: 862541-45-5

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PF-00610355 (PF-610355)

货号: PC-61871Not For Human Use, Lab Use Only.

PF-00610355 (PF 610355) is a potent, selective, and long-acting β2-adrenoreceptor agonist with EC50 of 0.26 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-00610355 (PF 610355) is a potent, selective, and long-acting β2-adrenoreceptor agonist with EC50 of 0.26 nM.
    PF-00610355 displays 220-fold selectivity over β1.
    PF-00610355 exhibits potential as inhaled ultra-long-acting bronchodilators for the treatment of asthma and chronic obstructive pulmonary disease.

    物理化学性质&存储条件

    分子量 617.76
    分子式 C34H39N3O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((4'-hydroxy(1,1'-biphenyl)-3-yl)methyl)-3-(2-(((2R)-2-hydroxy-2-(4-hydroxy-3-((methylsulfonyl)amino)phenyl)ethyl)amino)-2-methylpropyl)-benzeneacetamide

    参考文献

    1. Glossop PA, et al. J Med Chem. 2010 Sep 23;53(18):6640-52.

    2. Diderichsen PM, et al. Br J Clin Pharmacol. 2013 Nov;76(5):752-62.

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