PERK activator MK-28 (MK28)

Chemical Structure : PERK activator MK-28

CAS No.: 864388-65-8

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货号: PC-72030Not For Human Use, Lab Use Only.

PERK activator MK-28 (MK28) is a potent, selective small molecule PERK activator with EC50 of 490 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PERK activator MK-28 (MK28) is a potent, selective small molecule PERK activator with EC50 of 490 nM.
MK-28 shows little or no effect on EIF2AK1 (HRI) or EIF2AK2 (PKR), weakly activated EIF2AK4 (GCN2) with EC50 of 3.5 uM, also displays high selectivity on a panel of 391 kinases.
MK-28 rescues cells from ER stress-induced apoptosis.
MK-28 is predicted to interact with the PERK activation loop and its cellular protective effect is PERK-dependent and more potent than CCT020312.
MK-28 exhibits brain penetrance and improves neurological functions in the R6/2 HD mouse model.
MK-28 improves systemic function and survival in R6/2 mice and induces increased levels of eIF2α-P in the mouse brain striatum.

物理化学性质&存储条件

分子量	396.45
分子式	C24H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzaldehyde, 3,4-dihydroxy-, 2-(4,6-diphenyl-2-pyrimidinyl)-2-methylhydrazone

参考文献

1. Javier Ganz, et al. Sci Rep. 2020 Apr 23;10(1):6875.