PDE3B inhibitor 8a | PDE3B inhibitor | Probechem Biochemicals

Chemical Structure : PDE3B inhibitor 8a

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PDE3B inhibitor 8a (PDE3B-IN-2)

货号: PC-25898Not For Human Use, Lab Use Only.

PDE3B inhibitor 8a (PDE3B-IN-2) is a potent, subtype selective, orally active PDE3B inhibitor with IC50 of 0.19 nM and 1.3 nM for PDE3B and PDE3A respectively.

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生物&药学活性

PDE3B inhibitor 8a (PDE3B-IN-2) is a potent, subtype selective, orally active PDE3B inhibitor with IC50 of 0.19 nM and 1.3 nM for PDE3B and PDE3A respectively.
PDE3B inhibitor 8a is 7-fold selective for PDE3B over 3A.
PDE3B inhibitor 8a caused a dose dependent increase in glycerol levels, with an ED50=0.60 mg/kg in anesthetized rats.
PDE3B inhibitor 8a stimulated lipolysis in adipocytes with an ED50=0.6 mg/kg.
PDE3B inhibitor 8a showed a significant lowering of blood pressure in the rat at doses as low as 0.01 mg/kg.

物理化学性质&存储条件

分子量	387.48
分子式	C24H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(4-((2-benzyl-3-oxocyclohex-1-en-1-yl)amino)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

参考文献

1. Edmondson SD, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3983-7.

PDE3B inhibitor 8a (PDE3B-IN-2)

生物&药学活性

物理化学性质&存储条件

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PDE3B inhibitor 8a (PDE3B-IN-2)

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物理化学性质&存储条件

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