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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PDE1 inhibitor 4b
PDE1 inhibitor 4b

Chemical Structure : PDE1 inhibitor 4b

CAS No.:

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PDE1 inhibitor 4b

货号: PC-25390Not For Human Use, Lab Use Only.

PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway.

物理化学性质&存储条件

分子量 423.42
分子式 C24H19F2NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-1-(5-Fluoro-2-isopropoxybenzylidene)-6-(4-fluorobenzyl)furo[3,4-c] pyridine-3,4(1H,5H)-dione

参考文献

1. Jiang MY, et al. J Med Chem. 2025 Aug 22. doi: 10.1021/acs.jmedchem.5c01238.

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