欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-PD 404182
PD 404182

Chemical Structure : PD 404182

CAS No.: 72596-74-8

加入收藏

PD 404182 (PD404182, PD-404182)

货号: PC-60661Not For Human Use, Lab Use Only.

PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2480 In stock
25 mg ￥4580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
PD 404182 significantly increases intracellular levels of ADMA and reduces LPS-induced NO production in cultured primary human vascular endothelial cells (ECs).
PD 404182 abrogates the formation of tube-like structures by ECs in in vitro angiogenesis assay.
PD 404182 also shows anti-HIV and anti-HSV activites.

物理化学性质&存储条件

分子量 217.29
分子式 C11H11N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine

参考文献

1. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.

2. Mizuhara T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2079-87.

3. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.

4. Chamoun-Emanuelli AM, et al. Antimicrob Agents Chemother. 2014;58(2):687-97.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: