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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-PD318088
PD318088

Chemical Structure : PD318088

CAS No.: 391210-00-7

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PD318088 (PD 318088;PD-318088)

货号: PC-42877Not For Human Use, Lab Use Only.

PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

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PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

物理化学性质&存储条件

分子量 561.0891
分子式 C16H13BrF3IN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

参考文献

1. Han S, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73.

2. Zhang Y, et al. Mol Med Rep. 2014 Jan;9(1):83-90.

3. Ohren JF, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.

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