PBT434 |CAS:1232841-78-9 Probechem Biochemicals

Chemical Structure : PBT434

CAS No.: 1232841-78-9

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PBT434 (PBT-434)

货号: PC-35124Not For Human Use, Lab Use Only.

PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease.

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5 mg	￥5980	In stock
10 mg	￥8980	In stock
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生物&药学活性

PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease.
PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology.
PBT434 prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.

物理化学性质&存储条件

分子量	383.067
分子式	C12H14BrCl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3H)-one hydrobromide

参考文献

1. Finkelstein DI, et al. Acta Neuropathol Commun. 2017 Jun 28;5(1):53.

PBT434 (PBT-434)

生物&药学活性

物理化学性质&存储条件

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PBT434 (PBT-434)

生物&药学活性

物理化学性质&存储条件

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