PB151 | HDAC11 inhibitor | Probechem Biochemicals

Chemical Structure : PB151

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PB151 (PB-151)

货号: PC-28552Not For Human Use, Lab Use Only.

PB151 is a highly potent and isoform-selective HDAC11 inhibitor with IC50 of 59 nM, displays > 172-fold selectivity margin over all other class I, IIa, and IIb HDAC isoforms.

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生物&药学活性

PB151 is a highly potent and isoform-selective HDAC11 inhibitor with IC50 of 59 nM, displays > 172-fold selectivity margin over all other class I, IIa, and IIb HDAC isoforms.
PB151 selectively engages HDAC11 in cells and inhibits its intracellular defatty-acylase activity.
PB151 suppresses HCC proliferation and induces apoptosis, inhibiting the growth of HepG2, MHCC97-L, and HuH-7 cells with IC50 values of 5.50 uM, 7.08 uM, and 6.67 uM respectively (72 h of exposure).
PB151 (30 mg/kg once daily, i.p.) suppresses tumor progression in an endogenous orthotopic HCC model.
PB151 treatment improves liver histology and downregulates Ki67 expression in orthotopic hepatocellular carcinoma model.
PB151 treatment alters fatty acid metabolism and reduces lipid accumulation in hepatocellular carcinoma.
PB151 restricts lipogenesis via activation of the LKB1-AMPK signaling axis.

物理化学性质&存储条件

分子量	515.65
分子式	C31H37N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(adamantan-1-yl)propyl)-1-(4-(hydroxycarbamoyl)-3-methoxybenzyl)-1H-indole-5-carboxamide

参考文献

1. Wang W, et al. Eur J Med Chem. 2026 Oct 19;321(Pt 2):119430.

PB151 (PB-151)

生物&药学活性

物理化学性质&存储条件

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PB151 (PB-151)

生物&药学活性

物理化学性质&存储条件

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