欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HSV-PAV-174
PAV-174

Chemical Structure : PAV-174

CAS No.: 3034860-02-8

加入收藏

PAV-174 (PAV174)

货号: PC-25997Not For Human Use, Lab Use Only.

PAV-174 is a host protein-targeted antiviral compound that specifically interacts with an oxidized conformer of MIF (oxMIF), inhibits HSV-1 replication in a dose-dependent manner in HSV-1-infected Vero cells, both in a standard plaque assay and in an in-cell ELISA with an IC50 of 34 or 21 nM, respectively.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PAV-174 is a host protein-targeted antiviral compound that specifically interacts with an oxidized conformer of MIF (oxMIF), inhibits HSV-1 replication in a dose-dependent manner in HSV-1-infected Vero cells, both in a standard plaque assay and in an in-cell ELISA with an IC50 of 34 or 21 nM, respectively.
PAV-174 binds MIF at its multimerization interface.
PAV-174 reduces tau phosphorylation also in the absence of infection in an MIF- and dose-dependent manner.
PAV-174 inhibit oxMIF-induced tau phosphorylation in vitro and in 2-month-old male tgTau58/2 mice independent of infection.

物理化学性质&存储条件

分子量 414.01
分子式 C23H28ClN3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Phenothiazin-5-ium, 1-ethyl-9-methyl-3,7-di-1-pyrrolidinyl-, chloride (1:1)

参考文献

1. Müller-Schiffmann A, et al. Cell Rep Med. 2025 Dec 18:102520.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: