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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-PAT-1102
PAT-1102

Chemical Structure : PAT-1102

CAS No.: 2641930-61-0

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PAT-1102 (FNDR-20123, PAT1102)

货号: PC-24698Not For Human Use, Lab Use Only.

PAT-1102 (FNDR-20123) is a novel, potent, orally available HDAC inhibitor with IC50 of 3 nM in cell-free HDAC enzymatic assays, also inhibits Plasmodium HDAC with IC50 of 31 nM.

规格 价格 库存 数量
2 mg ￥1580 In stock
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PAT-1102 (FNDR-20123) is a novel, potent, orally available HDAC inhibitor with IC50 of 3 nM in cell-free HDAC enzymatic assays, also inhibits Plasmodium HDAC with IC50 of 31 nM.
PAT-1102 (FNDR-20123) inhibits P. falciparum in asexual blood-stage assay with IC50 of 42 nM.
PAT-1102 (FNDR-20123) shows activities against various HDAC isoforms, HDAC1, 2, 3, 6 and 8.
PAT-1102 (FNDR-20123) induces caspase-3 activation in HT-29 cells with EC50 of 1.36 uM.
PAT-1102 (FNDR-20123) exhibits growth-inhibitory properties against a panel of cancer cell lines.
PAT-1102 (FNDR-20123) (50 mg/kg, p.o.) induces significant dose-dependent tumor growth inhibition in subcutaneous xenograft model established with HCT-116 colorectal carcinoma cells in SCID mice.
PAT-1102 (FNDR-20123) exhibits vivo efficacy in a mouse model for Plasmodium falciparum infection.

物理化学性质&存储条件

分子量 413.91
分子式 C21H24ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-hydroxy-4-[[4-[4-(1-pyrrolidinylmethyl)phenyl]-1H-1,2,3-triazol-1-yl]methyl]-, hydrochloride (1:1)

参考文献

1. Hiriyan J, et al. Anticancer Res. 2015 Jan;35(1):229-37.

2. Vijay Potluri, et al. Malar J. 2020 Oct 12;19(1):365.

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