PARP7 inhibitor B-6

Chemical Structure : PARP7 inhibitor B-6

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货号: PC-27584Not For Human Use, Lab Use Only.

PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM.
PARP7 inhibitor B-6 demonstrated efficacy across multiple stroke models, significantly reducing cerebral infarct volume in the rat tMCAO model, and in both the rat tMCAO and mouse dMCAO models, suppressing acute inflammatory cytokine production and promoting sustained neurological and sensorimotor recovery.

物理化学性质&存储条件

分子量	341.27
分子式	C15H11F4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(4-fluorobenzoyl)azetidin-1-yl)-4-(trifluoromethyl)pyridazin-3(2H)-one

参考文献

1. Yan W, et al. Eur J Med Chem. 2026 Aug 5;318:119184.