PARP11 inhibitor ITK7 | PARP11 inhibitor | Probechem Biochemicals

Chemical Structure : PARP11 inhibitor ITK7

CAS No.: 2411890-36-1

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PARP11 inhibitor ITK7 (ITK7)

货号: PC-35720Not For Human Use, Lab Use Only.

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.
ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation (EC50=13 nM) in HeLa cells, does not inhibit H2O2-activated PARP1 autoPARylation, causes PARP11 to dissociate from the nuclear envelope.

物理化学性质&存储条件

分子量	322.386
分子式	C17H14N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-methyl-7-(prop-1-yn-1-yl)-2-((pyrimidin-2-ylthio)methyl)quinazolin-4(3H)-one

参考文献

1. Kirby IT, et al. Cell Chem Biol. 2018 Oct 18. pii: S2451-9456(18)30331-3

PARP11 inhibitor ITK7 (ITK7)

生物&药学活性

物理化学性质&存储条件

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PARP11 inhibitor ITK7 (ITK7)

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物理化学性质&存储条件

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