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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-PARP10-15 inhibitor 8l
PARP10-15 inhibitor 8l

Chemical Structure : PARP10-15 inhibitor 8l

CAS No.: 2892065-01-7

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PARP10-15 inhibitor 8l (PARP10/15-IN-1)

货号: PC-25417Not For Human Use, Lab Use Only.

PARP10-15 inhibitor 8l (PARP10/15-IN-1) is a potent, dual inhibitor of mono-ADP-ribosyltransferases PARP10 and PARP15 with IC50 of 160 nM and 370 nM respectively, inactive against the other mono-ARTs, PARP12 and PARP16.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PARP10-15 inhibitor 8l (PARP10/15-IN-1) is a potent, dual inhibitor of mono-ADP-ribosyltransferases PARP10 and PARP15 with IC50 of 160 nM and 370 nM respectively, inactive against the other mono-ARTs, PARP12 and PARP16.

物理化学性质&存储条件

分子量 274.29
分子式 C13H10N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3-Dihydro-6-(3-thienylmethoxy)-1,4-phthalazinedione

参考文献

1. Nizi MG, et al. Eur J Med Chem. 2022 Jul 5;237:114362.

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