PAPTP

Chemical Structure : PAPTP

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货号: PC-62646Not For Human Use, Lab Use Only.

PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.

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生物&药学活性

PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
PAPTP kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells.
PAPTP significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma.

物理化学性质&存储条件

分子量	780.639
分子式	C42H38IO5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-(4-(4-((7-oxo-7H-furo[3,2-g]chromen-4-yl)oxy)butoxy)phenyl)propyl)triphenylphosphonium iodide

参考文献

1. Leanza L, et al. Cancer Cell. 2017 Apr 10;31(4):516-531.e10.

PAPTP

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PAPTP

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