PAMT-001 | ERRα inverse agonist | Probechem Biochemicals

Chemical Structure : PAMT-001

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PAMT-001 (PAMT001)

货号: PC-26466Not For Human Use, Lab Use Only.

PAMT-001 is a potent inverse agonist of ERRα with EC50 of 0.17 uM, effectively binds to the ERRα ligand-binding domain, interacts with and inhibits ERRα through cooperation with PGC1α, effectively suppresses tumorigenesis.

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生物&药学活性

PAMT-001 is a potent inverse agonist of ERRα with EC50 of 0.17 uM, effectively binds to the ERRα ligand-binding domain, interacts with and inhibits ERRα through cooperation with PGC1α, effectively suppresses tumorigenesis.
PAMT-001 is potently cytotoxic against various cancer cell lines through mitochondria mediated apoptosis.
PAMT-001 inhibits mtOXPHOS and impairs mitochondrial respiration in various cancer cells.
PAMT-001 triggers autophagy for CHOP signaling and apoptosis.
PAMT-001 induces pyroptotic cell death via GSDME cleavage.
PAMT-001 inhibited tumor growth without causing toxicity in colorectal cancer xenograft model.

物理化学性质&存储条件

分子量	434.34
分子式	C18H16F6N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxybenzylidene)hydrazine-1-carboximidamide

参考文献

1. Seo W, et al. Cell Death Discov. 2026 Mar 26. doi: 10.1038/s41420-026-03010-4.

PAMT-001 (PAMT001)

生物&药学活性

物理化学性质&存储条件

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PAMT-001 (PAMT001)

生物&药学活性

物理化学性质&存储条件

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