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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-PAD inhibitor 4f
PAD inhibitor 4f

Chemical Structure : PAD inhibitor 4f

CAS No.:

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PAD inhibitor 4f

货号: PC-25372Not For Human Use, Lab Use Only.

PAD inhibitor 4f is a potent peptidylarginine deiminases (PAD) inhibitor with IC50 of 23 nM and 10 nM for PAD2 and PAD4 respectively, demonstrates potent inhibition of PAD-mediated citrullination in human and rat neutrophils (IC50=30 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PAD inhibitor 4f is a potent peptidylarginine deiminases (PAD) inhibitor with IC50 of 23 nM and 10 nM for PAD2 and PAD4 respectively, demonstrates potent inhibition of PAD-mediated citrullination in human and rat neutrophils (IC50=30 nM).

物理化学性质&存储条件

分子量 524.45
分子式 C26H27Cl2N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-amino-2-(1-(5-(3,5-dichloro-6-(1-methyl-1H-pyrazol-3-yl)pyridin-2-yl)isoquinolin-1-yl)piperidin-4-yl)-N-methylacetamide

参考文献

1. Schnute ME, et al. ACS Med Chem Lett. 2025 Jul 9;16(8):1662-1669.

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