PAD-PF2

Chemical Structure : PAD-PF2

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货号: PC-24594Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PAD-PF2 is a potent inhibitor of peptidylarginine deiminases (PAD1-4) with IC50 of 42.7 nM for PAD4 mediated citrullination in the fluorescent quenching assay, inhibits all four catalytically active PAD1-4 with comparable potency in a Ca2+-dependent manner.
PAD-PF2 binds similarly to both PAD4 and PAD2.
PAD-PF2 showed > 80-fold selectivity against a diverse panel of receptors, enzymes, kinases, transporters, and ion channels.
PAD-PF2 inhibits ionomycin induced protein citrullination in human isolated neutrophils.
PAD-PF2 could fully inhibited CitH3 detected protein citrullination with IC50 of 1.0 uM, also able to fully inhibit F95 detected protein citrullination (IC50 = 1.5 uM).

物理化学性质&存储条件

分子量	484.43
分子式	C25H27Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-2-(1-(5-(3,5-dichloropyridin-2-yl)isoquinolin-1-yl)piperidin-4-yl)-1-(pyrrolidin-1-yl)ethan-1-one

参考文献

1. Dakin LA, et al. Nat Commun. 2025 May 16;16(1):4579.

PAD-PF2

生物&药学活性

物理化学性质&存储条件

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PAD-PF2

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物理化学性质&存储条件

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