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首页-小分子抑制剂&激动剂-GPCR-Adenosine Receptor-P626
P626

Chemical Structure : P626

CAS No.: 2586198-02-7

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P626

货号: PC-25759Not For Human Use, Lab Use Only.

P626 is a potent, selective dual adenosine A2A/A2B receptor (A2AR/A2BR) antagonist with IC50 of 5.73 nM and 34 nM at both hA2AAR and hA2BAR (cAMP assay), with no significant acitivity against hA1AR and hA3AR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

P626 is a potent, selective dual adenosine A2A/A2B receptor (A2AR/A2BR) antagonist with IC50 of 5.73 nM and 34 nM at both hA2AAR and hA2BAR (cAMP assay), with no significant acitivity against hA1AR and hA3AR.
P626 efficiently prevented A2AR- and A2BR-dependent responses in OPCs, a mechanism consistent with its protective effects in EAE mice.
P626 treatment mitigated myelin loss and restored basal myelin levels in spinal cord samples from EAE mice.

物理化学性质&存储条件

分子量 416.47
分子式 C17H16N6O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-((7-Amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidin-5-yl)amino)ethyl)benzenesulfonamide

参考文献

1. F. Varano, et al. Bioorganic & Medicinal Chemistry Letters 30 (2020): 127067.

2. M Morozzi, et al. J Cell Mol Med. 2025 Nov;29(22):e70952.

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