P4HB inhibitor 2a

Chemical Structure : P4HB inhibitor 2a

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货号: PC-25629Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

P4HB inhibitor 2a is a tau-aggregate clearing compound (EC50=0.18 uM) that covalently targets protein disulfide isomerase 1 (P4HB, PDIA1), shows maximal tau clearance of 91% with no observable cytotoxicity.
P4HB inhibitor 2a likely undergoes metabolic activation to form a cysteine-reactive species that covalently modifies C397 of P4HB.
P4HB inhibitor 2a aminoindole potently clears aggregates in multiple tauopathy models, activates mild ER stress.

物理化学性质&存储条件

分子量	251.29
分子式	C15H13N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-N-phenyl-1H-indole-3-carboxamide

参考文献

1. Conway LP, et al. Cell Chem Biol. 2025 Oct 16;32(10):1235-1248.e34.