P1D-34 | Pin1 degrader | Probechem Biochemicals

Chemical Structure : P1D-34

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P1D-34 (Pin1 PROTAC degrader)

货号: PC-22075Not For Human Use, Lab Use Only.

P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%.

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生物&药学活性

P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%.
P1D-34 coupled the covalent Pin1 inhibitor Sulfopin to a cereblon ligand.
P1D-34 induces cell cycle arrest and apoptosis in AML cells, exhibits cell growth inhibitory activities with IC50 of 2-8 uM in a panel of AML cell lines: MV-4-11, MOLM-13, HL-60, THP-1, Kasumi-1, BDCM and OCI-AML3.
P1D-34 sensitizes ABT-199 against ABT-199-resistant AML cell lines, induces DNA damage and apoptosis by releasing ROS generation, and sensitizes 2-DG by down-regulating UPR pathways.

物理化学性质&存储条件

分子量	835.46
分子式	C40H59ClN6O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(2-chloro-N-((R)-1,1-dioxidotetrahydrothiophen-3-yl)acetamido)-2,2-dimethylpropyl)-N4-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)dodecyl)succinamide

参考文献

1. Yunkai Shi, et al. Chem Sci. 2024 Feb 28;15(13):5027-5035.

P1D-34 (Pin1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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P1D-34 (Pin1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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