Org43553 | LHR agonist | Probechem Biochemicals

Chemical Structure : Org43553

CAS No.: 501444-88-8

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Org43553 (Org 43553, Org-43553)

货号: PC-26422Not For Human Use, Lab Use Only.

Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.

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2 mg	￥2380	In stock
5 mg	￥3780	In stock
10 mg	￥5780	In stock
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100 mg		Get quote

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生物&药学活性

Org 43553 (Org43553) is a selective allosteric agonist of luteinizing hormone-choriogonadotropin receptor (LHCGR, LHR) with EC50 of 4.7 nM.
Org 43553 interacts with the endodomain of the LHR, whereas LH acts via the N-terminal exodomain.
Org 43553 inhibits luteinizing hormone (LH)-induced phospholipase C (PLC) with IC50 of 10 nM.

物理化学性质&存储条件

分子量	514.66
分子式	C24H30N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Amino-N-(tert-butyl)-2-(methylthio)-4-(3-(2-morpholinoacetamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide

参考文献

1. Duan J, et al. Nature. 2021 Oct;598(7882):688-692.

2. van Koppen, C. J. et al. Naunyn Schmiedebergs Arch. Pharmacol. 378, 503–514 (2008).

Org43553 (Org 43553, Org-43553)

生物&药学活性

物理化学性质&存储条件

参考文献

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Org43553 (Org 43553, Org-43553)

生物&药学活性

物理化学性质&存储条件

参考文献

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