Orcinol gentiobioside

Chemical Structure : Orcinol gentiobioside

CAS No.: 164991-86-0

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货号: PC-28545Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Orcinol gentiobioside (OGB) is a specific small molecule inhibitor of Catalase-peroxidase 1 (KatG1), targets KatG1 (MST Kd=0.62 uM) and inhibits its nuclear translocation, effectively suppressing the ROS scavenging capacity, inhibiting M. oryzae invasion in rice.
Orcinol gentiobioside (OGB) binds within the catalytic pocket of KatG1.
Orcinol gentiobioside (OGB) treatment (10 μM) successfully disrupted the KatG1-Ssb1 interaction in wild-type strains, thereby reducing KatG1 nuclear accumulation and impairing ROS scavenging capacity.
Orcinol gentiobioside (OGB) directly inhibits KatG1 catalase activity and decreases the expression of oxidoreduction pathway-related genes.
Orcinol gentiobioside (OGB) does not inhibit the in vitro catalase activity of its recombinant paralog KatG2 purified from Escherichia coli.
Orcinol gentiobioside (OGB) inhibits virulence of the rice blast fungus.
KatG1 acts as a ROS-responsive regulatory enzyme and is essential for M. oryzae to adapt to oxidative stress.
Orcinol gentiobioside (OGB) also inhibits RANKL-induced osteoclastogenesis by promoting apoptosis and suppressing autophagy via the JNK1 signaling.

物理化学性质&存储条件

分子量	448.42
分子式	C19H28O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5S,6R)-2-(3-hydroxy-5-methylphenoxy)-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triol

参考文献

1. Ren Z, et al. Nat Commun. 2026 Sep 14;17(1):10774.

2. Lian C, et al. J Ethnopharmacol. 2024 Jun 28;328:118060.